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card
defect
attack
rare
Hyperbeam is a very powerful aoe attack with a serious downside. It can be used to tear through act one hallway fights very quickly, but as soon as you reach act 2 it becomes less consistent and the focus down begins to take its toll. I normally only consider taking this card if my deck does not rely on orbs at all, but almost every single defect deck does even to a small degree. The one that comes to mind is all for one. It can also be played with other focus down effects such as reprogram, since after losing a certain amount of focus anymore losses don't make any difference. Note that plasma is unaffected by focus.

Pen Nib
common
Every 10th Attack you play deals double damage.
B

Vajra
common
At the start of each combat, gain 1 Strength.
A

Molten Egg
uncommon
Whenever you add an Attack card to your deck, it is Upgraded.
A-

Shuriken
uncommon
Every time you play 3 Attacks in a single turn, gain 1 Strength.
B

Snecko Eye
boss
Draw 2 additional cards each turn. Start each combat Confused.
A-

Velvet Choker
boss
Gain 1 Energy at the start of each turn. You cannot play more than 6 cards per turn.
A

Sling of Courage
shop
Start each Elite combat with 2 Strength.
D+

Pocketwatch
rare
Whenever you play 3 or less cards in a turn, draw 3 additional cards at the start of your next turn.
C-

Data Disk
common
Start each combat with 1 Focus.
B+

Symbiotic Virus
uncommon
At the start of each combat, Channel 1 Dark.
B-

Inserter
boss
Every 2 turns, gain 1 Orb Slot.
A

Runic Capacitor
shop
Start each combat with 3 additional Orb slots.
B

Frozen Core
boss
Replaces Cracked Core. If you end your turn with empty Orb slots, channel 1 Frost.
A-