Health Sacrifice

power

Rupture

1

D-

Whenever you lose HP from a card, gain 1 Strength.

power

Combust

1

C-

At the end of your turn, lose 1 HP and deal 5 damage to ALL enemies.

power

Brutality

0

B-

At the start of your turn, lose 1 HP and draw 1 card.

attack

Hemokinesis

1

C+

Lose 2 HP.
Deal 15 damage.

skill

Offering

0

A+

Lose 6 HP.
Gain .
Draw 3 cards.
Exhaust.

skill

Bloodletting

0

B-

Lose 3 HP.
Gain .

attack

Blood for Blood

4

D+

Costs 1 less for each time you lose HP in combat.
Deal 18 damage.

attack

Reaper

2

A

Deal 4 damage to ALL enemies. Heal for unblocked damage.
Exhaust.

This build focuses on using self-damaging cards like Brutality and Combust in combination with Rupture to consistently gain Strength. Rupture can be stacked multiple times to accelerate battles but note that multiple copies of Brutality only trigger health loss once, so only grant one strength per turn. The same goes for Combust (though Brutality and Combust do at least trigger separately).

skill

Bandage Up

0

S-

Heal 4 HP.
Exhaust.

curse

Pain

Unplayable.
While in hand, lose 1 HP when other cards are played.

attack

Whirlwind

X

B+

Deal 5 damage to ALL enemies X times.

attack

Heavy Blade

2

C

Deal 14 damage.
Strength affects Heavy Blade 3 times.

attack

Pummel

1

C

Deal 2 damage 4 times.
Exhaust.

attack

Sword Boomerang

1

C-

Deal 3 damage to a random enemy 3 times.

skill

J.A.X.

0

B+

Lose 3 HP.
Gain 2 Strength.

attack

Bite

1

B+

Deal 7 damage.
Heal 2 HP.

Magic Flower

rare

Healing is 50% more effective during combat.

B+

Self-Forming Clay

uncommon

Whenever you lose HP in combat, gain 3 Block next turn.

D+

Blue Candle

uncommon

Curse cards can now be played. Playing a Curse will make you lose 1 HP and Exhausts the card.

C-

D+

D+

D+

Runic Cube

uncommon

Whenever you lose HP, draw 1 card.

B+

Black Blood

boss

Replaces Burning Blood. At the end of combat, heal 12 HP.

C+

To pull this strategy off, it's important to include not only self-damaging cards like Hemokinesis, Offering, and Bloodletting but also cards that can benefit from the strength gain, like Heavy Blade, Whirlwind or Limit Break. Blood for Blood offers a powerful, low-cost attack that synergizes well with this deck. Healing options are important to sustain you through multiple fights - Reaper is a particular stand out in this regard since it also synergises with strength.

There are other more niche ways to lose health such as through curses or relics but these are not required nor to be relied upon. I will give Pain a special call-out since it can trigger Rupture several times in a turn, but it relies on Rupture being active first.

Don't skimp on the card draw and remember to include defensive options or your health will whittle away much faster than you can manage.