Catalyst

Catalyst is perhaps the single highest damage card the silent has access to. Although it requires some setup, it can turn boss encounters into an absolute joke. Be wary of bosses who can remove their debuffs, such as the champ and the time eater, because otherwise you will have to begin stacking poison all over again. Having 2 copies of catalyst makes it much more consistent, as sometimes you draw the first copy too early before there is significant poison on the target, and sometimes when you are cycling through the deck for the second time you might find that you are waiting on it for too long. Also, the difference between three times as much poison and nine times as much poison is extremely significant. Catalyst is a brilliant target for nightmare for this reason. Make sure not to pull the trigger too early on this card, as tripling five damage is considerably worse than tripling 20 damage.